The PAPP-A test – its new application

PAPP-A test – when is it done?

The PAPP-A test is the colloquial name for a composite test performed in the first trimester. The test is based on the joint evaluation of a genetic ultrasound and biochemical parameters – PAPP-A protein, free beta-HCG and PlGF. The PAPP-A test should be performed between the 11th and 14th week of pregnancy. At this time, an ultrasound examination should be performed and blood should be drawn from the expectant mother. The gynaecologist then enters all the data into a special computer and the patient can receive the complete result of the test including the blood samples.

PAPP-A test – why is it worth doing?

The PAPP-A test was originally developed primarily to assess the risk of chromosomal abnormalities. Some people still deliberately choose not to take this test because they believe that knowing that the baby has a genetic defect will not change their management or the further course of the pregnancy. However, not everyone is aware that this test also determines the risk of pre-eclampsia. This makes it possible to take appropriate precautions and reduce the risk of pre-eclampsia. For this reason, it is advisable not to skip the PAPP-A test.

PAPP-A test result

With the PAPP-A test, in addition to the ultrasound examination, the risk of chromosomal abnormalities and especially the risk of pre-eclampsia is calculated for each patient. Depending on the result of the test, the further procedure is determined. If the risk of chromosomal aberrations is between 1:300 and 1:1000, a fetal DNA test is recommended, while if the risk is greater than 1:300, an invasive diagnosis such as amniocentesis is suggested. If the pre-eclampsia risk is higher than 1:150, the pregnant woman should take 150 mg of acetylsalicylic acid per night until the 36th week of pregnancy. It is important to take this prophylaxis before the 16th week, when the placenta has not yet fully formed.