Where are
stem cells used?

Development of stem cell therapy

Umbilical cord blood was successfully used for the first time in 1988 in France. Since then umbilical cord blood was used over 85 000 times for therapies in hospitals around the world. Samples from Stemlab were released for the first time in 2007.

Currently stem cells from the cord blood are used in medicine as a standard therapy in 80 diseases, there are also clinical trials that use cord blood for both stem cell transplants and emerging therapies in regenerative medicine. See the list of diseases published and revised by EBMT – European Society for Blood and Marrow Transplantion.

List of medical conditions treated with stem cells

Acute leukaemias

acute lymphoblastic leukaemia (ALL)

acute myeloid leukaemia (AML)

acute biphenotipic leukaemia

poorly differentiated acute leukaemia

Chronic leukaemias

chronic myeloid leukaemia (CML)

chronic lymphocytic leukaemia (CLL)

juvenile chronic myeloid leukaemia (JCML)

juvenile myelomonocytic leukaemia (Naegeleg leukaemia) (JMML)

Myelodisplastic syndrome

refractory anaemia (RA)

refractory anaemia with ringed sideroblasts (RARS)

refractory anaemia with excess blasts (RAEB)

refractory anaemia with excess blasts in transformation (RAEB-T)

chronic myelomonocytic leukaemia (CMML)

Diseases caused by stem cell defect

aplastic anaemia(severe)

Fanconi anaemia

paroxysmal nocturnal haemoglobinuria

Myeloproliferative syndromes

acute myelofibrosis

myelofibrosis

polycythaemia vera

Essentials thromb ocythemia

Hyperplastic disorders of lymphatic system

non-Hodgkin lymphoma

acute lymphogranuloma

prolimphocytic leukaemia

Phagocytic disorders

Chediak-Higashi syndrome

chronic granulomatous disease (CGD)

neutrophil actin dysfunction

reticular dysgenesis

Disorders caused by the absence or malfunctioning of enzymes

mucopolysaccharidoses MPS)

Scheie syndrome (MPS-IS)

Hunter syndrome (MPS-II)

Sanfilippo syndrome (MPS-III)

Morquio syndrome (MPS-IV)

Maroteaux-Lamy syndrome (MPS-VI)

Sly syndrome, beta- glucoronidase deficiency (MPS-VII)

adrenoleukodystrophy

mucolipidosis II

Krabbe disease

Gaucher disease

Niemann-Pick disease

Wolman disease

metachromatic leukodystrophy

Histiocytic disorders

familial erythrophagocytic lymphohistiocytosis

histiocytosis -X

hemophagocytosis

Inherited red blood cell abnormalities

beta thalassemia

pure red cell aplasia

sickle cell anaemia

Inherited immune system disorders

telangiectasia

Kostmann syndrome

leukocyte adhesion deficiency

DiGeorge syndrome

bare lymphocyte syndrome

Omenn syndrome

severe combined immunodeficiency (SCID)

SCID adenosine deaminase deficiency

SCID T and B lymphocytes negative

SCID T lymphocytes negative and B lymphocytes positive

common variable immunodeficiency

Wiskotta Aldrich syndrome

X-linked lymphoproliferative disorder

Other inherited conditions

Lesch-Nyhan syndrome

cartilage-hair hypoplasia

Glanzmann’s thrombasthenia

osteopetrosis (marble bone disease)

Hereditary thrombotic disorders

mega-karyocytosis (inherited thrombocythemia)

Plasma cell disorders

multiple myeloma

plasmocythic leukaemia

Waldenström’s macroglobulinemia

Other forms of cancer

breast cancer

Ewing’s sarcoma

neuroblastoma (sympathicoblastoma)

kidney cancer

Where are stem cells used?

Development of stem cell therapy

Use of stem cells brings benefits to patients with neurological disorders such as: autism and cerebral palsy

Where are
stem cells used?